Coxsackievirus is a member of the Picornaviridae family of viruses in the genus termed Enterovirus. Coxsackieviruses are subtype members of Enterovirus that have a single strand of ribonucleic acid (RNA) for its genetic material.
The enteroviruses are also referred to as picornaviruses (pico means “small,” so “small RNA viruses”). Coxsackie virus was first isolated from human feces in the town of Coxsackie, N.Y., in 1948 by G. Dalldorf. Coxsackie virus is also written as coxsackievirus in some publications.